Actually, I think it’s kind of funny

After the announcement of the Nobel Prize, the Nobel Committee calls the award recipients. This reveals their first reactions. These interviews are published with Bengali translations for the readers of "Views Bangladesh" collected from the Nobel Committee's website. In 2024, the Nobel Prize in Chemistry was awarded to three American scientists: David Baker, Demis Hassabis, and John M Jumper. Today, David Baker's first reaction has been published.

News of the 2024 Nobel Prize in Chemistry gave David Baker’s household a very early wake up call. Here, just after the prize announcement, he talks about the exciting potential of building brand new proteins, the inspirational effect his fellow laureates have had on his field and whether it is necessary to understand how predictive algorithms work.

David Baker: Hello?
Adam Smith: Oh, hello. Is this David Baker?

David Baker: It is, yes. I’m still listening. I’m in the press conference.
Adam Smith: Oh, I do apologise. If you want to finish listening to the press conference, I can hang on,

David Baker: Let me just go through the rest of the press conference and then then we can talk. Would that be all right?
Adam Smith: Certainly. I’ll phone you back as soon as it’s finished.

David Baker: Hello?
Adam Smith: Hi, it’s Adam Smith again from the website of the Nobel Prize. Many congratulations.

David Baker: Thank you.
Adam Smith: Can you just tell me how the news reached you?

David Baker: Let’s see. Well, actually I think it’s kind of funny. I didn’t realise this till afterwards, but I think they had the phone number for my son who then gave them my phone number. And so I got a phone call, and my wife promptly started screaming, so I had a little hard time hearing, but then they got the news across
Adam Smith: I like that she twigged before you did.

David Baker: Yes.
Adam Smith: I mean, people always said there’d be a Nobel Prize for the people to solve the protein folding problem, and here it is. How does it feel?

David Baker: It is well, of course it’s a great honor and it is very exciting and it’s great to share this with Demis and, really John Jumper in particular, who really solved the classic structure prediction problem. You know, for protein design, I always thought that if there was a Nobel Prize, I’d be sharing it with Steve Mayo and Bill DeGrado. So I’m a little sorry about that. But yes, I think it’s neat to have you know, there’s always been two sides to the protein folding problem going from sequence to structure and then back from structure to sequence. And I think it’s neat that that there’s a Nobel Prize for them together.
Adam Smith: Yes, united. What do you think is going be the most beneficial effect of protein design in the foreseeable future?

David Baker: I’m really optimistic about really a wide range of applications. So just thinking about the things that we’re working on now, in health and medicine, I think smarter therapeutics that are more precise, and act only in the right time and place in the body, could get around a lot of the problems of systemic drugs.
We have the first really de novo design medicine that’s been approved for use in humans. That’s a vaccine designed by my colleague Neil King at the Institute for Protein Design. Then outside of medicine, I think we’re making great strides now in developing new catalysts, and that could be for things like breaking down pollutants and plastics and things in the environment to coming up with sort of greener chemistry, you know, better routes to new molecules. I think there’s a lot of sustainability applications, you know, once you start just thinking about all the different things proteins do in nature that, and they really just evolved over random chance over, you know, over millions of years of natural selection. Now with the ability to design new proteins, specifically to solve problems there’s just so many possibilities. It’s really exciting.
Adam Smith: It’s a whole new world, isn’t it? Gosh.

David Baker: It’s a whole new world. Yes, it really is.
Adam Smith: Yes. Just lastly, on the protein folding question, how does it feel being awarded with basically your competitors? Because you know, for a while, RoseTTAFold and AlphaFold were sort of, you know, competing with each other. How does it feel to be united in this prize?

David Baker: I’ve never really felt that DeepMind or John or Demis were competitors. I think it was very inspiring. We were developing physically based methods for protein structure prediction and protein design for many years, and we were making progress on protein design and being able to design, you know, more complicated protein functions. But it was continued progress. But then, when John developed AlphaFold2, it was really kind of a wake up call for me to the power of deep learning, so rather than competitors, I really would say they’ve been great inspirers about the power of deep learning. I think that a lot of the most exciting things that we’ve done in the recent years have come from the deep learning methods that we’ve developed who really you know, really inspired that machine learning to have so much power in this field from John and Demis’s work.
Adam Smith: It may be too big a question for now, but as you said, basically the protein folding question was going be solved by understanding, but in the end it got solved by not understanding the rules. Does it matter that the rules are not understood? But it works?

David Baker: That’s a big question. I think for the many, many uses that protein structure prediction has had, that knowing protein structures have, it doesn’t really matter so much how you get there. And humans are very comfortable with solving problems every day with a very, very complicated neural network that we really don’t understand at all; our brain. We’re quite comfortable with the solutions we come up with, and we don’t have a lot of anxiety about not understanding exactly how our brains work.
Adam Smith: All fascinating. Thank you. Just for now, it’s crazily early in the morning there, what happens next?

David Baker: I think while we’ve been on the phone, I think I’ve had the decline about a hundred phone calls and the messages keep cropping up. I think I’m gonna try and get some sleep. I don’t know if that’s possible. But yes, it’s going to be quite a day.
Adam Smith: It will, it would put you among a select group of laureates who’ve managed to do that. So good luck. I hope it works.

David Baker: Yes, I’m not very optimistic, so … [laughs] it’s very exciting.
Adam Smith: Okay. Once again, congratulations David.

David Baker: Nice talking to you.
Adam Smith: Thank you. Bye. Bye.

Source: nobelprize.org